Simulation of Multicellular Tumor Spheroids Growth by Cellular Automata with Asynchronous Update. Branislav Brutovsky, Denis Horvath and Vladimir Lisy

The cellular automata with asynchronous update are used to generate the close-to-circular 2-dimensional objects revealing the desired features, such as the velocity of the growth and the fractal behavior of their contours. The approach enables to reproduce and analyze some of the recent findings in morphometric analysis of real tumors with the possible implications for cancer research. The technique is based on cellular automata paradigm with the transition rules searched for by genetic algorithms.